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Anna, later known as Chenoa, is the lone survivor of an Indian attack by a band of Chickasaw hunters. She uses the food supplies and tools from the wagons as a bargaining tool to help the tribe, which in turn will spare her life.
Determined to make a new existence for herself regardless of the circumstances, she falls in love with her captor, Ohiteka. Chenoa overcomes and accepts the cultural differences she encounters, struggles to survive when taken from her new home by the Choctaw Indians, enemies of the Chickasaw, and does not give up when rescued by Hurritt, a would-be friend of Ohiteka, only to be brought back to her village as his slave. Hurritt’s actions ensured that she would never be with Ohiteka.